Case of isolated adrenocorticotropic hormone deficiency mimicking major depressive disorder

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概要 症例 は56才,男 性.54才 時 よ り食欲不 振が 出現,昭 和59年,低Na血 症 にて入院.昭 和60 年4月 よ り悪 心,嘔 吐 出現 し当科 紹介.血 清Naの 最低値は105mEq/1.血 中コ ルチ ゾール,尿 中17-OHCSの 著 しい基 礎低値.血 漿ACTH基 礎 値 は測定 感度 以下 で,イ ンス リン低 血糖, L8-V,CRFに 無反 応.他 の下垂体前 葉ホル モ ン正常.ACTH単 独 欠損症 と診 断,画 像診 断上empty sellaが確認 された.低Na血 症下 のACTH-Z負 荷 にてコルチ ゾール,17-OHCSLは 増加 し,自 由 水 ク リア ラ ンス は一0.85~ 一0.95m1/分 よ りほぼ0に 至 り,低Na血 症 は改善, ADHは1.4→0.5 pg/mlと 低下 した.本 例 の低Na血 症 に はグルコ...

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A case of isolated ACTH deficiency accompanying transient primary hypothyroidism was reported along with a review of literature on isolated ACTH deficiency in Japan with special reference to its association with thyroid function. Our case, a 56-year-old woman, developed somnolence and hypoglycemia due to isolated ACTH deficiency. She also had the features of hypothyroidism, namely mounding phen...

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ژورنال

عنوان ژورنال: Psychiatry and Clinical Neurosciences

سال: 2011

ISSN: 1323-1316

DOI: 10.1111/j.1440-1819.2011.02207.x